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Article

Soluble epoxide hydrolase dimerization is required for hydrolase activity.

The Journal of biological chemistry - 15 Mar 2013

Nelson Jonathan W, Subrahmanyan Rishi M, Summers Sol A, Xiao Xiangshu, Alkayed Nabil J

Abstract excerpt

Soluble epoxide hydrolase (sEH) plays a key role in the metabolic conversion of the protective eicosanoid 14,15-epoxyeicosatrienoic acid to 14,15-dihydroxyeicosatrienoic acid. Accordingly, inhibition of sEH hydrolase activity has been shown to be beneficial in multiple models of cardiovascular diseases, thus identifying sEH as a valuable therapeutic target. Recently, a common human polymorphism (R287Q) was...

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Identifiers

PMID: 23362272
DOI: 10.1074/jbc.M112.429258
PMCID: PMC3597810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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