Article
Soluble epoxide hydrolase: gene structure, expression and deletion.
Gene - 10 Sept 2013
Harris Todd R, Hammock Bruce D
Abstract excerpt
Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols through the addition of a water molecule. sEH readily hydrolyzes lipid signaling molecules, including the epoxyeicosatrienoic acids (EETs), epoxidized lipids produced from arachidonic acid by the action of cytochrome p450s. Through its metabolism of the EETs and other lipid mediators, sEH contributes to the regulation of...
Topics
- Animals
- Catalysis
- Disease Models, Animal
- Epoxide Hydrolases
- Evolution, Molecular
- Gene Expression
- Gene Expression Regulation
- Humans
- Mice
- Mice, Knockout
- Polymorphism, Single Nucleotide
- Protein Conformation