Novel Potential Binding Sites for Selective Inhibitor Design of Human Soluble Epoxide Hydrolase

Abstract excerpt

<title>Abstract</title> <p>Human soluble epoxide hydrolase (hsEH) has been known to be involved in the hydrolysis of epoxyeicosatrienoic acids (EETs), which are anti-inflammatory and cardioprotective signalling molecules. Since the conversion of EETs into the corresponding diols generates non-bioactive molecules, the enzyme’s inhibition would be beneficial. hsEH quickly became the molecular target, however, the p...

Topics

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• Binding Sites
• Heat-Shock Proteins
• Models, Chemical
• Molecular Chaperones
• Molecular Dynamics Simulation
• Protein Conformation
• Protein Domains
• Reproducibility of Results

Identifiers and source

Literature Corpus work

79c31160-1d2a-5de7-a759-1823b2b0adf0

DOI

10.21203/rs.3.rs-29814/v1