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Article

Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation.

Journal of lipid research - 1 Jun 2014

Morisseau Christophe, Wecksler Aaron T, Deng Catherine, Dong Hua, Yang Jun, Lee Kin Sing S, Kodani Sean D, Hammock Bruce D

Abstract excerpt

Epoxy FAs (EpFAs) are important lipid mediators that are mainly metabolized by soluble epoxide hydrolase (sEH). Thus, sEH inhibition is a promising therapeutic target to treat numerous ailments. Several sEH polymorphisms result in amino acid substitutions and alter enzyme activity. K55R and R287Q are associated with inflammatory, cardiovascular, and metabolic diseases. R287Q seems to affect sEH activity through...

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

Share to Protein Multimerization

Source

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Identifiers

PMID: 24771868
DOI: 10.1194/jlr.M049718
PMCID: PMC4031944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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