Article

Shared associations identify causal relationships between gene expression and immune cell phenotypes

2020-09-20

Abstract excerpt

Genetic mapping studies have identified thousands of associations between common variants and hundreds of human traits. Translating these associations into mechanisms is complicated by two factors: they fall into gene regulatory regions; and they are rarely mapped to one causal variant. One way around these limitations is to find groups of traits that share associations, using this genetic link to infer a biologic...

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Literature Corpus work: fbb7951c-2e56-5f52-8e08-3bfac3b13210
DOI: 10.1101/2020.09.19.304832

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