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Article

Associations of genetic variants with gene expression factors reveal biological pathways underlying complex traits.

American journal of human genetics - 2 Apr 2026

Sun Xiaotong, LaPierre Nathan, Gu Jing, Tan Wenchang, He Xin

Abstract excerpt

Genome-wide association studies (GWASs) have mapped a large number of variants associated with common traits and diseases. To translate these associations into mechanistic knowledge, it is important to understand the downstream genes and biological processes that mediate the effects of these variants on phenotypes. One strategy to link trait-associated genetic variants with their downstream target genes is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41932315
DOI: 10.1016/j.ajhg.2026.03.004
PMCID: PMC13049358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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