Article

Mycobacterial infection uncovers plasticity of Kupffer cells

2025-02-08

Abstract excerpt

Bona fide Kupffer cells (KCs) are prenatally seeded and show unique functional and immunophenotypic features among tissue macrophages. They are considered as terminally differentiated, and adaptability in disease is attributed to recruited, monocyte-derived KCs. Here, we investigated the extent of KC plasticity and the impact of origin in mycobacterial infections that target macrophages and can persist for months....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fbb44c8d-ac45-5b2d-b2c7-d35579a57281
DOI: 10.1101/2025.02.07.636999

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mycobacterial infection uncovers plasticity of Kupffer cellsDOI 10.1101/2025.02.07.636999Read

Macrophage Differentiation and Metabolic Adaptation in Mycobacterial InfectionsSemantic proximity Read

Understanding the Heterogeneity of Resident Liver Macrophages.Semantic proximity Read

Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells.Semantic proximity Read

Macrophage Plasticity: Phenotypic and Functional Profiles Across Pathological Microenvironments.Semantic proximity Read

Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases.Semantic proximity Read

Availability of an inflammatory macrophage niche drives phenotypic and functional alterations in Kupffer cellsSemantic proximity Read

Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formationSemantic proximity Read

Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis GranulomasSemantic proximity Read

Large-Scale Gene Expression Signatures Reveal a Microbicidal Pattern of Activation in Mycobacterium leprae-Infected Monocyte-Derived Macrophages With Low Multiplicity of Infection.Semantic proximity Read

In vivo single cell transcriptomics reveals Klebsiella pneumoniae rewiring of lung macrophages to promote infectionSemantic proximity Read

Functional specialization of short-lived and long-lived macrophage subsets in human tonsils.Semantic proximity Read

A multicenter spatial transcriptomics atlas of human tuberculosis and non-tuberculous mycobacterial diseaseSemantic proximity Read