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Article

Functional specialization of short-lived and long-lived macrophage subsets in human tonsils.

The Journal of experimental medicine - 3 Jul 2023

Alaoui Lamine, Villar Javiera, Leclere Renaud, Le Gallou Simon, Relouzat Francis, Michaud Henri-Alexandre, Tarte Karin, Teissier Natacha, Favier Benoît, Roussel Mikaël, Segura Elodie

Abstract excerpt

Macrophages play a central role in tissue homeostasis and host defense. However, the properties of human macrophages in non-diseased tissues remain poorly understood. Here, we characterized human tonsil macrophages and identified three subsets with distinct phenotype, transcriptome, life cycle, and function. CD36hi macrophages were related to monocytes, while CD36lo macrophages showed features of embryonic origin...

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Identifiers

PMID: 37036425
DOI: 10.1084/jem.20230002
PMCID: PMC10098144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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