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Article

Macrophage Plasticity: Phenotypic and Functional Profiles Across Pathological Microenvironments.

International journal of molecular sciences - 12 Jun 2026

Falda Alessandra

Abstract excerpt

Macrophages are highly plastic innate immune cells that adopt context-dependent phenotypes along a continuum, integrating developmental origin with local microenvironmental cues rather than conforming to discrete M1/M2 states. This review delineates the molecular circuits shaping macrophage identity-TLR/cytokine signaling, microRNA networks, metabolic rewiring, and epigenetic mechanisms including histone...

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Identifiers

PMID: 42353053
DOI: 10.3390/ijms27125333
PMCID: PMC13300302

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