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A multicenter spatial transcriptomics atlas of human tuberculosis and non-tuberculous mycobacterial disease

2025-10-17

Abstract excerpt

<h4>Summary</h4> Granulomas are the hallmark of mycobacterial (MB) infections, forming structured immune environments that contain bacteria but also drive disease persistence. However, their spatial and functional organization remains unclear. Using spatial RNA sequencing on 38 patient samples, we identified five distinct granuloma niches: a necrotic core, an immune-activated inner niche, an inflammatory and an e...

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Literature Corpus work
75d84c0a-e975-552c-aeed-ca6408978c75
DOI
10.1101/2025.10.17.683002
Open publication

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A multicenter spatial transcriptomics atlas of human tuberculosis and non-tuberculous mycobacterial diseaseDOI 10.1101/2025.10.17.683002
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