Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases.

doi:10.1093/femspd/ftw068

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Article

Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases.

Pathogens and disease - 1 Oct 2016

McClean Colleen M, Tobin David M

Abstract excerpt

Macrophages play a central role in mycobacterial pathogenesis. Recent work has highlighted the importance of diverse macrophage types and phenotypes that depend on local environment and developmental origins. In this review, we highlight how distinct macrophage phenotypes may influence disease progression in tuberculosis. In addition, we draw on work investigating specialized macrophage populations important in...

Topics

Animals
Chemotaxis, Leukocyte
Granuloma
Humans
Lipid Metabolism
Macrophages
Mononuclear Phagocyte System
Mycobacterium tuberculosis
Phagocytosis
Phenotype
Tuberculosis

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Identifiers

PMID: 27402783
DOI: 10.1093/femspd/ftw068
PMCID: PMC5985490

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