Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells.

Abstract excerpt

Inflammatory signals lead to recruitment of circulating monocytes and induce their differentiation into pro-inflammatory macrophages. Therefore, whether blocking inflammatory monocytes can mitigate disease progression is being actively evaluated. Here, we employ multiple lineage-tracing models and show that monocyte-derived macrophages (mo-mac) are the major population of immunosuppressive, liver...

Topics

Join the communities discussing this publication.

• Cell Plasticity
• Inflammation
• Kupffer Cells
• Liver
• Liver Neoplasms