Article

In vivo single cell transcriptomics reveals Klebsiella pneumoniae rewiring of lung macrophages to promote infection

2021-10-19

Abstract excerpt

The strategies deployed by antibiotic resistant bacteria to counteract host defences are poorly understood. Here, we elucidate a novel host-pathogen interaction that results in the control of lung macrophage polarisation by the human pathogen Klebsiella pneumoniae. We identify interstitial macrophages (IMs) as the main population of lung macrophages associated with Klebsiella. Single cell transcriptomics and traje...

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Literature Corpus work: 53935f69-f10f-505f-a4a9-631bc0dc08a2
DOI: 10.1101/2021.10.18.464784

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