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Article

EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease.

Journal of lipid research - 1 Sept 2017

Tai Leon M, Balu Deebika, Avila-Munoz Evangelina, Abdullah Laila, Thomas Riya, Collins Nicole, Valencia-Olvera Ana Carolina, LaDu Mary Jo

Abstract excerpt

Identified in 1993, APOE4 is the greatest genetic risk factor for sporadic Alzheimer's disease (AD), increasing risk up to 15-fold compared with APOE3, with APOE2 decreasing AD risk. However, the functional effects of APOE4 on AD pathology remain unclear and, in some cases, controversial. In vivo progress to understand how the human (h)-APOE genotypes affect AD pathology has been limited by the lack of a...

Topics

Alzheimer Disease
Animals
Apolipoprotein E4
Disease Models, Animal
Humans
Mice
Mice, Transgenic
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28389477
DOI: 10.1194/jlr.R076315
PMCID: PMC5580905

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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