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Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease

18 Jan 2005

Abstract excerpt

Apolipoprotein E (apoE) alleles are important genetic risk factors for Alzheimer's disease (AD), with the epsilon4 allele increasing and the epsilon2 allele decreasing risk for developing AD. ApoE has been shown to influence brain amyloid-beta peptide (Abeta) and amyloid burden, both in humans and in transgenic mice. Here we show that direct intracerebral administration of lentiviral vectors expressing the three...

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PMID: 15657137
DOI: 10.1073/pnas.0409072102

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