Article
Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Apr 2012
Bien-Ly Nga, Gillespie Anna K, Walker David, Yoon Seo Yeon, Huang Yadong
Abstract excerpt
Apolipoprotein E4 (apoE4) plays a major role in the pathogenesis of Alzheimer's disease. Brain amyloid-β (Aβ) accumulation depends on age and apoE isoforms (apoE4 > apoE3) both in humans and in transgenic mouse models. Brain apoE levels are also isoform dependent, but in the opposite direction (apoE4 < apoE3). Thus, one prevailing hypothesis is to increase brain apoE expression to reduce Aβ levels. To test this...
Topics
- Aging
- Amyloid beta-Protein Precursor
- Animals
- Apolipoprotein E3
- Apolipoprotein E4
- Apolipoproteins E
- Female
- Gene Knock-In Techniques
- Humans
- Male
- Mice