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Article

Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Apr 2012

Bien-Ly Nga, Gillespie Anna K, Walker David, Yoon Seo Yeon, Huang Yadong

Abstract excerpt

Apolipoprotein E4 (apoE4) plays a major role in the pathogenesis of Alzheimer's disease. Brain amyloid-β (Aβ) accumulation depends on age and apoE isoforms (apoE4 > apoE3) both in humans and in transgenic mouse models. Brain apoE levels are also isoform dependent, but in the opposite direction (apoE4 < apoE3). Thus, one prevailing hypothesis is to increase brain apoE expression to reduce Aβ levels. To test this...

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Identifiers

PMID: 22492035
DOI: 10.1523/JNEUROSCI.0033-12.2012
PMCID: PMC3433173

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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