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Article

Introducing Human <i>APOE</i> into A<i>β</i> Transgenic Mouse Models

1 Jan 2011

Abstract excerpt

Apolipoprotein E (apoE) and apoE/amyloid-β (Aβ) transgenic (Tg) mouse models are critical to understanding apoE-isoform effects on Alzheimer's disease risk. Compared to wild type, apoE(-/-) mice exhibit neuronal deficits, similar to apoE4-Tg compared to apoE3-Tg mice, providing a model for Aβ-independent apoE effects on neurodegeneration. To determine the effects of apoE on Aβ-induced neuropathology, apoE(-/-)...

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Identifiers

PMID: 22028984
DOI: 10.4061/2011/810981

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