Article
Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Dec 2011
Kim Jungsu, Jiang Hong, Park Seonha, Eltorai Adam E M, Stewart Floy R, Yoon Hyejin, Basak Jacob M, Finn Mary Beth, Holtzman David M
Abstract excerpt
The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease (AD). Evidence suggests that the effect of apoE isoforms on amyloid-β (Aβ) accumulation in the brain plays a critical role in AD pathogenesis. Like in humans, apoE4 expression in animal models that develop Aβ amyloidosis results in greater Aβ and amyloid deposition than with apoE3 expression. However,...
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