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Comparison of the ApoE allelic variants in the formation of intracerebral Aβ deposits.

Neurobiology of disease - 1 Nov 2025

Xu Guilian, Angelle Conner, Huilgol Divya, Sacilotto Patricia, McFarland Karen N, Fromholt Susan, Lopez Amanda, Vo Quan, Rivasplata Andrea, Brkic Selma, Gorski Carmelina, Bali Parul, Lu Qing, Borchelt David R, Chakrabarty Paramita

Abstract excerpt

The Apolipoprotein E (APOE) isoforms APOE2, APOE3 and APOE4 differentially modulate risk of Alzheimer's disease (AD). Despite established evidence for APOE's impact on Aβ deposition, the differential effects of APOE genotypes on distinct forms of amyloid pathology remain poorly understood. The three primary types of amyloid pathology in the brain are dense-cored fibrillar plaques, diffuse Aβ deposits, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40962157
DOI: 10.1016/j.nbd.2025.107105

Genes

APOE
APP

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