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Article

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.

The Journal of biological chemistry - 7 Dec 2012

Youmans Katherine L, Tai Leon M, Nwabuisi-Heath Evelyn, Jungbauer Lisa, Kanekiyo Takahisa, Gan Ming, Kim Jungsu, Eimer William A, Estus Steve, Rebeck G William, Weeber Edwin J, Bu Guojun, Yu Chunjiang, Ladu Mary Jo

Abstract excerpt

APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with amyloid-β peptide (Aβ) suggest interactions among apoE isoforms and different forms of Aβ accumulation. However, it remains unclear how the APOE genotype affects plaque morphology, intraneuronal Aβ, soluble...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23060451
DOI: 10.1074/jbc.M112.407957
PMCID: PMC3516726

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23060451-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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