Article

Structural modeling of cytokine-receptor-JAK2 signaling complexes using AlphaFold Multimer

2023-06-14

Abstract excerpt

Homodimeric class 1 cytokine receptors include the erythropoietin (EPOR), thrombopoietin (TPOR), granulocyte colony-stimulating factor 3 (CSF3R), growth hormone (GHR), and prolactin receptors (PRLR). They are cell-surface single-pass transmembrane (TM) glycoproteins that regulate cell growth, proliferation, and differentiation and induce oncogenesis. An active TM signaling complex consists of a receptor homodimer,...

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Literature Corpus work: fb397a48-e263-5258-9b98-78aa13ef1fa6
DOI: 10.1101/2023.06.14.544971

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