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Article

Modulation of human thrombopoietin receptor conformations uncouples JAK2 V617F-driven activation from cytokine-induced stimulation.

Blood - 23 Nov 2023

Papadopoulos Nicolas, Pristavec Ajda, Nédélec Audrey, Levy Gabriel, Staerk Judith, Constantinescu Stefan N

Abstract excerpt

The thrombopoietin receptor (TpoR) plays a central role in myeloproliferative neoplasms (MPNs). Mutations in JAK2, calreticulin, or TpoR itself drive the constitutive activation of TpoR and uncontrolled proliferation and differentiation of hematopoietic stem cells and progenitors. The JAK2 V617F mutation is responsible for most MPNs, and all driver mutants induce pathologic TpoR activation. Existing therapeutic...

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PMID: 37616564
DOI: 10.1182/blood.2022019580

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