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Article

Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation.

eLife - 25 Jul 2018

Ferrao Ryan D, Wallweber Heidi Ja, Lupardus Patrick J

Abstract excerpt

Cytokines and interferons initiate intracellular signaling via receptor dimerization and activation of Janus kinases (JAKs). How JAKs structurally respond to changes in receptor conformation induced by ligand binding is not known. Here, we present two crystal structures of the human JAK2 FERM and SH2 domains bound to Leptin receptor (LEPR) and Erythropoietin receptor (EPOR), which identify a novel dimeric...

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Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Erythropoietin

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Source

Open in PubMed Open full text

Identifiers

PMID: 30044226
DOI: 10.7554/eLife.38089
PMCID: PMC6078494

Genes

JAK2
EPOR
LEPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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