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Article

Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling.

Science advances - 8 Mar 2024

Abraham Bobin George, Haikarainen Teemu, Vuorio Joni, Girych Mykhailo, Virtanen Anniina T, Kurttila Antti, Karathanasis Christos, Heilemann Mike, Sharma Vivek, Vattulainen Ilpo, Silvennoinen Olli

Abstract excerpt

Janus kinase 2 (JAK2) mediates type I/II cytokine receptor signaling, but JAK2 is also activated by somatic mutations that cause hematological malignancies by mechanisms that are still incompletely understood. Quantitative superresolution microscopy (qSMLM) showed that erythropoietin receptor (EpoR) exists as monomers and dimerizes upon Epo stimulation or through the predominant JAK2 pseudokinase domain mutations...

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Identifiers

PMID: 38457493
DOI: 10.1126/sciadv.adl2097
PMCID: PMC10923518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling.PMID 38457493Read ↗

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