Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.

Science (New York, N.Y.) - 8 Apr 2022

Glassman Caleb R, Tsutsumi Naotaka, Saxton Robert A, Lupardus Patrick J, Jude Kevin M, Garcia K Christopher

Abstract excerpt

Cytokines signal through cell surface receptor dimers to initiate activation of intracellular Janus kinases (JAKs). We report the 3.6-angstrom-resolution cryo-electron microscopy structure of full-length JAK1 complexed with a cytokine receptor intracellular domain Box1 and Box2 regions captured as an activated homodimer bearing the valine→phenylalanine (VF) mutation prevalent in myeloproliferative neoplasms. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Cryoelectron Microscopy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 1

Share to Myeloproliferative Disorders

Share to Protein Multimerization

Share to Receptors, Cytokine

Share to src Homology Domains

Share to STAT Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 35271300
DOI: 10.1126/science.abn8933
PMCID: PMC9306331

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.PMID 35271300Read ↗

Structural Analysis of Janus Tyrosine Kinase Variants in Hematological Malignancies: Implications for Drug Development and Opportunities for Novel Therapeutic Strategies.Semantic proximity Read ↗

The use of structural biology in Janus kinase targeted drug discovery.Semantic proximity Read ↗

Structures of the interleukin 11 signalling complex reveal dynamics of gp130 extracellular domains and the inhibitory mechanism of a cytokine variantSemantic proximity Read ↗

Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling.Semantic proximity Read ↗

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.Semantic proximity Read ↗

Ab initio modeling and experimental assessment of Janus Kinase 2 (JAK2) kinase-pseudokinase complex structure.Semantic proximity Read ↗

The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural ComplexitiesSemantic proximity Read ↗

Crystal Structure of the FERM-SH2 Module of Human Jak2.Semantic proximity Read ↗

Structural modeling of cytokine-receptor-JAK2 signaling complexes using AlphaFold MultimerSemantic proximity Read ↗

The molecular regulation of Janus kinase (JAK) activationSemantic proximity Read ↗

Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix.Semantic proximity Read ↗

The Janus kinases (Jaks)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.