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IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions

28 Sept 2020

Abstract excerpt

Cytokines of the IL-12 family show structural similarities but have distinct functions in the immune system. Prominent members of this cytokine family are the pro-inflammatory cytokines IL-12 and IL-23. These two cytokines share cytokine subunits and receptor chains but have different functions in autoimmune diseases, cancer and infections. Accordingly, structural knowledge about receptor complex formation is...

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PMID: 32998371
DOI: 10.3390/cells9102184

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