Article

Shared and distinct sequence-function signatures define different modes of human TpoR activation

2025-09-13

Abstract excerpt

<h4>ABSTRACT</h4> The human thrombopoietin receptor (hTpoR) exists primarily as JAK2-associated monomers that become activated when converted to dimeric forms that support JAK trans-phosphorylation. This can be achieved by several different modes of stimuli, including the natural ligand Tpo, biologic agonists that bind the same site as Tpo, small-molecule drugs that bind the transmembrane (TM) domain, oncogenic m...

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Literature Corpus work: ab5b5326-70a4-5fd4-b6e8-e5676594088b
DOI: 10.1101/2025.09.09.675271

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