Rationalizing 5000-fold differences in receptor-binding rate constants of four cytokines.

Abstract excerpt

The four cytokines erythropoietin (EPO), interleukin-4 (IL4), human growth hormone (hGH), and prolactin (PRL) all form four-helix bundles and bind to type I cytokine receptors. However, their receptor-binding rate constants span a 5000-fold range. Here, we quantitatively rationalize these vast differences in rate constants by our transient-complex theory for protein-protein association. In the transient complex,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cytokines
• Share to Kinetics
• Share to Models, Molecular