Article

A force-sensitive mutation reveals a spindle assembly checkpoint-independent role for dynein in anaphase progression

2023-08-04

Abstract excerpt

<h4>ABSTRACT</h4> The cytoplasmic dynein-1 (dynein) motor organizes cells by shaping microtubule networks and moving a large variety of cargoes along them. However, dynein’s diverse roles complicate in vivo studies of its functions significantly. To address this issue, we have used gene editing to generate a series of missense mutations in Drosophila Dynein heavy chain (Dhc). We find that mutations associated w...

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Literature Corpus work: faca7c82-29b6-5884-9a52-bb7c9332cd25
DOI: 10.1101/2023.08.03.551815

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