Article

Genetic analysis of dynein function in the nervous system and in mitosis

2020-01-01

Abstract excerpt

Cytoplasmic dynein-1 is an essential microtubule-based molecular motor. Aided by several adaptors and co-factors, dynein orchestrates retrograde transport of diverse cargoes in interphase cells and plays multiple roles in mitosis. The importance of this motor is underlined by the fact that mutations in Dynein heavy chain, the motor-containing subunit of dynein, cause neurological disorders in humans. How dynein ex...

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Literature Corpus work: 55f4907b-9236-57b0-9db3-bcd00650a187
DOI: 10.17863/cam.64452

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