Article

Pathogenic Mutations in the Kinesin-3 Motor KIF1A Diminish Force Generation and Movement Through Allosteric Mechanisms

2020-09-03

Abstract excerpt

<h4>ABSTRACT</h4> The kinesin-3 motor KIF1A functions in neurons where its fast and superprocessive motility is thought to be critical for long-distance transport. However, little is known about the force-generating properties of kinesin-3 motors. Using optical tweezers, we demonstrate that KIF1A and its C. elegans homolog UNC-104 undergo force-dependent detachments at ~3 pN and then rapidly reattach to the micr...

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Literature Corpus work: 32b75d54-d347-5643-bfd7-30e23ec57e62
DOI: 10.1101/2020.09.03.281576

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