Article
Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function.
Molecular biology of the cell - 1 Oct 2021
Denarier E, Ecklund K H, Berthier G, Favier A, O'Toole E T, Gory-Fauré S, De Macedo L, Delphin C, Andrieux A, Markus S M, Boscheron C
Abstract excerpt
Mutations in the genes that encode α- and β-tubulin underlie many neurological diseases, most notably malformations in cortical development. In addition to revealing the molecular basis for disease etiology, studying such mutations can provide insight into microtubule function and the role of the large family of microtubule effectors. In this study, we use budding yeast to model one such mutation-Gly436Arg in...
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