Article
Role of kinesin-1-based microtubule sliding in Drosophila nervous system development.
Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2016
Winding Michael, Kelliher Michael T, Lu Wen, Wildonger Jill, Gelfand Vladimir I
Abstract excerpt
The plus-end microtubule (MT) motor kinesin-1 is essential for normal development, with key roles in the nervous system. Kinesin-1 drives axonal transport of membrane cargoes to fulfill the metabolic needs of neurons and maintain synapses. We have previously demonstrated that kinesin-1, in addition to its well-established role in organelle transport, can drive MT-MT sliding by transporting "cargo" MTs along...
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