Article

Kinesin-binding protein remodels the kinesin motor to prevent microtubule-binding

2021-06-02

Abstract excerpt

<h4>ABSTRACT</h4> Kinesins are tightly regulated in space and time to control their activation in the absence of cargo-binding. Kinesin-binding protein (KIFBP) was recently discovered to bind the catalytic motor heads of 8 of the 45 known kinesin superfamily members and inhibit binding to microtubules. In humans, mutation of KIFBP gives rise to Goldberg-Shprintzen syndrome (GOSHS), but the kinesin(s) that is misr...

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Literature Corpus work: a813b4a2-3651-5a90-88a8-59f94897cfcb
DOI: 10.1101/2021.06.02.446814

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