Article

<i>DYNC1H1</i> mutations associated with neurological diseases compromise processivity of dynein-dynactin-cargo adaptor complexes

2016-12-09

Abstract excerpt

Mutations in the human DYNC1H1 gene are associated with neurological diseases. DYNC1H1 encodes the heavy chain of cytoplasmic dynein-1, a 1.4 MDa motor complex that traffics organelles, vesicles and macromolecules towards microtubule minus ends. The effects of the DYNC1H1 mutations on dynein motility, and consequently their links to neuropathology, are not understood. Here, we address this issue using a recombi...

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Literature Corpus work: 26944bbe-4c52-5fed-8e7d-027af6d45e8a
DOI: 10.1101/092791

Open publication

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