Article

Molecular basis for dyneinopathies reveals insight into dynein regulation and dysfunction

2019-05-10

Abstract excerpt

<h4>SUMMARY</h4> Cytoplasmic dynein plays critical roles within the developing and mature nervous systems, including effecting nuclear migration, and retrograde transport of various cargos. Unsurprisingly, mutations in dynein are causative of various developmental neuropathies and motor neuron diseases. These “dyneinopathies” define a broad spectrum of diseases with no known correlation between mutation identity...

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Literature Corpus work: 2e975ed0-1b2c-599b-a96f-923ec7e84e86
DOI: 10.1101/635383

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