Article
A force-sensitive mutation reveals a non-canonical role for dynein in anaphase progression.
The Journal of cell biology - 7 Oct 2024
Salvador-Garcia David, Jin Li, Hensley Andrew, Gölcük Mert, Gallaud Emmanuel, Chaaban Sami, Port Fillip, Vagnoni Alessio, Planelles-Herrero Vicente José, McClintock Mark A, Derivery Emmanuel, Carter Andrew P, Giet Régis, Gür Mert, Yildiz Ahmet, Bullock Simon L
Abstract excerpt
The diverse roles of the dynein motor in shaping microtubule networks and cargo transport complicate in vivo analysis of its functions significantly. To address this issue, we have generated a series of missense mutations in Drosophila Dynein heavy chain. We show that mutations associated with human neurological disease cause a range of defects, including impaired cargo trafficking in neurons. We also describe a...
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