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Article

Beyond the CNS: The many peripheral roles of APOE.

Neurobiology of disease - 1 May 2020

Martínez-Martínez Ana B, Torres-Perez Elena, Devanney Nicholas, Del Moral Raquel, Johnson Lance A, Arbones-Mainar Jose M

Abstract excerpt

Apolipoprotein E (APOE) is a multifunctional protein synthesized and secreted by multiple mammalian tissues. Although hepatocytes contribute about 75% of the peripheral pool, APOE can also be expressed in adipose tissue, the kidney, and the adrenal glands, among other tissues. High levels of APOE production also occur in the brain, where it is primarily synthesized by glia, and peripheral and brain APOE pools are...

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Identifiers

PMID: 32087284
DOI: 10.1016/j.nbd.2020.104809
PMCID: PMC7195217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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