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GDNF-engineered AMSC-derived exosomes attenuate renal interstitial fibrosis by promoting peritubular capillary regeneration via miR-29c-3p–IFN-γ–SIRT1 signaling

2026-08-04

Abstract excerpt

<title>Abstract</title> <p>Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial fibrosis and microvascular rarefaction. Peritubular capillary (PTC) loss exacerbates renal hypoxia and accelerates fibrotic progression; however, effective therapeutic strategies targeting PTC regeneration remain limited. Here, we investigated whether exosomes derived from glial cell line–derived neurotrophi...

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Literature Corpus work: 2511d7c0-5bc7-524c-b2ec-ddad39af1d79
DOI: 10.21203/rs.3.rs-9715010/v1

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