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Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

2020-02-18

Abstract excerpt

Chronic kidney disease (CKD) remains a major epidemiological, clinical and biomedical challenge. During CKD, renal tubular epithelial cells (TECs) suffer a persistent inflammatory and profibrotic response. Fatty acid oxidation (FAO), the main source of energy for TECs, is reduced in kidney fibrosis and contributes to its pathogenesis. To determine if FAO gain-of-function (FAO-GOF) could protect from fibrosis, we g...

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Literature Corpus work
60009c7d-3b7e-5541-8dc5-528022318d5a
DOI
10.1101/2020.02.18.952440
Open publication

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Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasisDOI 10.1101/2020.02.18.952440
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