Article
Modeling the evolutionary dynamics of clonal hematopoiesis.
Nature genetics - 1 Mar 2026
Marzban Sadegh, Stiehl Thomas, Xie Zhuoer, Andersen Morten, Snyder Jordan, Gudmand-Høyer Johanne, Ottesen Johnny T, Mon Père Nathaniel V, Werner Benjamin, Huang Weini, DeZern Amy E, Sekeres Mikkael A, Walter Matthew J, Padron Eric, Gillis Nancy, West Jeffrey
Abstract excerpt
Clonal hematopoiesis (CH) results from the acquisition and expansion of somatic mutations in hematopoietic stem and progenitor cells and is associated with age-related clinical sequelae, including an increased risk for cardiovascular disease, myeloid neoplasms and complications related to cancer therapy. Chemotherapy and radiation can accelerate CH expansion and further elevate the risk of adverse events,...
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