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Article

cloneRate: fast estimation of single-cell clonal dynamics using coalescent theory.

Bioinformatics (Oxford, England) - 2 Sept 2023

Johnson Brian, Shuai Yubo, Schweinsberg Jason, Curtius Kit

Abstract excerpt

MOTIVATION: While evolutionary approaches to medicine show promise, measuring evolution itself is difficult due to experimental constraints and the dynamic nature of body systems. In cancer evolution, continuous observation of clonal architecture is impossible, and longitudinal samples from multiple timepoints are rare. Increasingly available DNA sequencing datasets at single-cell resolution enable the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37699006
DOI: 10.1093/bioinformatics/btad561
PMCID: PMC10534056

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