Article

A fast 2C-induction method reveals a barrier role of SP2 for totipotency

2026-07-23

Abstract excerpt

The acquisition of totipotency in vitro remains a major challenge, limiting our understanding of early embryogenesis and its clinical and translational applications. Here, we reported a robust and rapid chemical reprogramming system that converts mouse embryonic stem cells (mESCs) into totipotent-like cells (TLCs) within 36 hours, with efficiencies exceeding 70%. The induced cells exhibit transcriptomic, epigenom...

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Identifiers and source

Literature Corpus work: 933f772e-b476-587a-ad18-0f4e4f666d26
DOI: 10.64898/2026.07.23.740258

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