Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance

11 Feb 2019

Abstract excerpt

Stem cell characteristics have been associated with treatment resistance and poor prognosis across many cancer types. The ability to induce and regulate the pathways that sustain these characteristic hallmarks of lethal cancers in a novel in vitro model would greatly enhance our understanding of cancer progression and treatment resistance. In this work, we present such a model, based simply on applying standard...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Pluripotent Stem Cells Research
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30742096
DOI: 10.1038/s41388-019-0712-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistancePMID 30742096Read ↗

Unlocking the Role of OCT4 in Cancer Lineage Plasticity: A Cross-Cancer Perspective with an Emphasis on Prostate CancerSemantic proximity Read ↗

Defining reprogramming checkpoints from single-cell analysis of induced pluripotencySemantic proximity Read ↗

NANOG reprograms prostate cancer cells to castration resistance via dynamically repressing and engaging the AR/FOXA1 signaling axisSemantic proximity Read ↗

Epithelial–Mesenchymal Transition Signaling and Prostate Cancer Stem Cells: Emerging Biomarkers and Opportunities for Precision TherapeuticsSemantic proximity Read ↗

Linking Pluripotency Reprogramming and Cancer.Semantic proximity Read ↗

Common stemness regulators of embryonic and cancer stem cellsSemantic proximity Read ↗

Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient SurvivalSemantic proximity Read ↗

The pluripotency factor Nanog is directly upregulated by the Androgen Receptor in prostate cancer cellsSemantic proximity Read ↗

Androgen Deprivation Induces Transcriptional Reprogramming in Prostate Cancer Cells to Develop Stem Cell-Like CharacteristicsSemantic proximity Read ↗

Isolation and functional interrogation of adult human prostate epithelial stem cells at single cell resolutionSemantic proximity Read ↗

Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signallingSemantic proximity Read ↗

NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.