Article

TridentTCR: Predicting T Cell Receptor Specificity for Antigens and Autoimmune-Related Targets via a Topology-Aware Graph and Large Language Model

2025-06-27

Abstract excerpt

T cells recognize and eliminate diseased cells by binding their T cell receptors (TCRs) to short endogenous peptides presented on the cell surface, commonly referred to as antigens. Accurate prediction of antigen–TCR specificity is essential for advancing T cell-based immunotherapies while minimizing autoimmune toxicity. However, current computational methods struggle to generalize across diverse TCR repertoires a...

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Literature Corpus work: f9cfe387-cff9-58d3-8a4e-0780e1e62380
DOI: 10.1101/2025.06.27.661632

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