Article

Sequence-based TCR-Peptide Representations Using Cross-Epitope Contrastive Fine-tuning of Protein Language Models

2024-10-29

Abstract excerpt

Understanding T-Cell receptor (TCR) and epitope interactions is critical for advancing our knowledge of the human immune system. Traditional approaches that use sequence similarity or structure data often struggle to scale and generalize across diverse TCR/epitope interactions. To address these limitations, we introduce ImmuneCLIP, a contrastive fine-tuning method that leverages pre-trained protein language models...

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Literature Corpus work: ac16530b-ed2b-59ac-b5c1-00996ba42797
DOI: 10.1101/2024.10.25.619698

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