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TCRconv: predicting recognition between T cell receptors and epitopes using contextualized motifs

6 Dec 2022

Abstract excerpt

MOTIVATION: T cells use T cell receptors (TCRs) to recognize small parts of antigens, called epitopes, presented by major histocompatibility complexes. Once an epitope is recognized, an immune response is initiated and T cell activation and proliferation by clonal expansion begin. Clonal populations of T cells with identical TCRs can remain in the body for years, thus forming immunological memory and potentially...

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PMID: 36477794
DOI: 10.1093/bioinformatics/btac788

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