Article

T-cell receptor specific protein language model for prediction and interpretation of epitope binding (ProtLM.TCR)

2022-11-29

Abstract excerpt

The cellular adaptive immune response relies on epitope recognition by T-cell receptors (TCRs). We used a language model for TCRs (ProtLM.TCR) to predict TCR-epitope binding. This model was pre-trained on a large set of TCR sequences (~62.10 6 ) before being fine-tuned to predict TCR-epitope bindings across multiple human leukocyte antigen (HLA) of class-I types. We then tested ProtLM.TCR on a balanced set of bin...

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Literature Corpus work: 00c74008-69bd-56f3-95c4-8f7ce4168b6c
DOI: 10.1101/2022.11.28.518167

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