Article

THLANet: A Deep Learning Framework for Predicting TCR-pHLA Binding in Immunotherapy Applications

2025-04-19

Abstract excerpt

Adaptive immunity is a targeted immune response that enables the body to identify and eliminate foreign pathogens, playing a critical role in the anti-tumor immune response. Tumor cell expression of antigens forms the foundation for inducing this adaptive response. However, the human leukocyte antigens (HLA)-restricted recognition of antigens by T-cell receptors (TCR) limits their ability to detect all neoantigens...

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Literature Corpus work: 5047a3d3-91bb-5ea9-b969-e90451fb7712
DOI: 10.1101/2025.04.14.648678

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