Article

Determining epitope specificity of T-cell receptors with transformers

2023-04-02

Abstract excerpt

<h4>Motivation</h4> T-cell receptors (TCR) on T cells recognize and bind to epitopes presented by the major histocompatibility complex (MHC) in case of an infection or cancer. However, the high diversity of TCRs, as well as their unique and complex binding mechanisms underlying epitope recognition, make it difficult to predict the binding between TCR and epitope. Here, we present the utility of transformers, a de...

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Literature Corpus work: bb1526f0-cd8c-5c83-adce-07c2fba2565b
DOI: 10.1101/2023.03.31.534974

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